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Mapping of H3K4 and H3K27 trimethylation in zebrafish cells (Gene expression)

ABSTRACT: The genomic distribution of post-translationally modified histones in the zebrafish (Danio rerio) genome remain largely unraveled. The objective of this study was to (1) design a microarray covering all zebrafish gene promoters and 5' end of coding regions, and (ii) using these arrrays, map the genome-wide distribution of trimethylated H3K4 and H3K27 in the embryo derived ZF4 cell line. Specifically, we determined the enrichment profile of H3K4me3, H3K27me3 and of both (co-enriched) modifications in ZF4 cells. We determined average enrichment profiles through metagene analysis, functional terms enriched among genes marked by either modification, pathway analysis, and in relation to gene expression.

ORGANISM(S): Danio rerio

PROVIDER: GSE23679 | GEO | 2011/02/08

SECONDARY ACCESSION(S): PRJNA133141

REPOSITORIES: GEO

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