Transcriptomics

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Paneth cell scRNA-seq analysis of un-infected and Salmonella Typhimurium infected mice


ABSTRACT: Paneth cells consist of heterogeous phenotypes. How Paneth cells respond to infection by invasive pathogenic bacteria at single cell level remains uncharacterized. We used a flow cytometry based method to isolate Paneth cells from uninfected and Salmonella-infected Paneth cell reporter mice (Lyz1-3'UTR-IRES-CreER; Rosa26R-tdTomato). These highly pure Paneth cell populations were used for single cell RNA sequencing analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE237326 | GEO | 2023/09/01

REPOSITORIES: GEO

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