Transcriptomics

Dataset Information

0

The Human Circular RNA CircHMGCS1 Sponges miR-4521 to Aggravates Diabetes-Induced Vascular Endothelial Dysfunction Through Upregulating ARG1


ABSTRACT: Cardiovascular diseases pose a significant global health burden. Our study investigates the pivotal role of circular RNAs (circRNAs) and MicroRNAs (miRNAs) in diabetes-induced endothelial dysfunction, a critical aspect of cardiovascular diseases. CircHMGCS1 (hsa_circ_0008621) emerges as a specific circRNA that effectively targets miR-4521. The upregulation of CircHMGCS1 acts as a miR-4521 sponge, facilitating the expression of arginase 1 and accelerating the progression of diabetes-induced endothelial dysfunction. Furthermore, intricate associations among circRNA, miRNA, and mRNA are revealed, illuminating the underlying molecular mechanisms involved in diabetes-induced vascular endothelial dysfunction. These findings significantly advance our understanding of cardiovascular diseases, providing potential therapeutic targets for intervention.

ORGANISM(S): Homo sapiens

PROVIDER: GSE237597 | GEO | 2024/08/08

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-08-08 | GSE237295 | GEO
2024-09-18 | GSE206809 | GEO
2019-11-27 | GSE137501 | GEO
2005-09-01 | E-MEXP-377 | biostudies-arrayexpress
2016-05-23 | GSE74296 | GEO
2023-11-23 | GSE235204 | GEO
2024-05-31 | GSE267493 | GEO
2019-01-15 | E-MTAB-6841 | biostudies-arrayexpress
2023-05-31 | GSE176531 | GEO
2021-09-09 | PXD019992 | Pride