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Transcription profiling of human coronary artery endothelial cells treated with ADMA at 2uM (a pathophysiological dose) and 100uM (a pharmacological dose), for 24h

ABSTRACT: Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in wide range of diseases associated with endothelial dysfunction and enhanced atherosclerosis. Plasma ADMA has been implicated as a major novel cardiovascular risk factor, but the mechanisms by which low concentrations of ADMA produce adverse effects on the cardiovascular system are unclear. We have treated human coronary artery endothelial cells with ADMA at 2uM (a pathophysiological dose) and 100uM (a pharmacological dose), for 24h.

ORGANISM(S): Homo sapiens

SUBMITTER: Mike Hubank

PROVIDER: E-MEXP-377 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.

Smith Caroline L CL Anthony Shelagh S Hubank Mike M Leiper James M JM Vallance Patrick P

PLoS medicine 20051004 10

<h4>Background</h4>Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in a wide range of diseases associated with endothelial dysfunction and enhanced atherosclerosis. Clinical studies implicate plasma ADMA as a major novel cardiovascular risk factor, but the mechanisms by which low concentrations of ADMA produce adverse effects on the cardiovascular system are unclear.<h4>Methods and findings</h4>We treated human coronary artery endo ...[more]

PMID: 16190779

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