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Single cell transcriptome signature of hepatocellular carcinoma (HCC) at different stages along with tumor development

ABSTRACT: HCC possesses a highly heterogeneous tumor micro-environment with dynamic populations and interaction along tumor progression. We used single cell RNA sequencing (scRNA-seq) to analyze cell composition and features of HCC. A subgroup of tumor-associated macrophages characterized with distinctive metabolic activity was identified. We further excavated its functional phenotype as well as interaction with other components and investigated the underlying molecular mechanism.

ORGANISM(S): Mus musculus

PROVIDER: GSE237823 | GEO | 2024/01/01

REPOSITORIES: GEO

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