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RNA sequencing analysis of IP (with GFP antibody) and Input samples of the mPFC of stressed DBA mice expressing GFP-L10a

ABSTRACT: We performed high-throughput profiling of gene expression in aPVT-projectors in the mPFC of DBA2/J mice subjected to subchronic and mild social defeat stress. DBA mice were subjected to 5-day of social defeat stress and then tested their social interaction and anhedonic state. After behavioral tests, mice were divided into five subtypes: SA, social interaction deficit, ANH: anhedonia, SA:ANH, both social dificit and anhedonia, RES, resilience and non-stressed (NS) control. Mice were euthanized for tissue collection. We then conducted the Immunoprecipitation and RNA-seq. Our study provided insights into the understanding of the molecular mechanisms underlying behavioral heterogeneity.

ORGANISM(S): Mus musculus

PROVIDER: GSE238142 | GEO | 2024/01/15

REPOSITORIES: GEO

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