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Diurnal gene expression profiles in mouse brain tissues constituting the central dopamine system

ABSTRACT: The circadian regulation of gene expression underlies orchestrated daily rhythms in physiology, metabolism, and behavior. The central dopamine (DA) system arising from DA neurons in the ventral midbrain has been implicated in a wide range of brain functions. Growing evidence suggests that DA transmission follows daily oscillations at multiple regulatory steps, and its dysfunction is closely related to the onset of various neuropsychiatric diseases. We examined diurnal gene expression profiles across key brain areas constituting the central DA pathways in mice by use of microarray analyses to identify rhythmically expressed genes according to the time of day (TOD).

ORGANISM(S): Mus musculus

PROVIDER: GSE238212 | GEO | 2024/05/20

REPOSITORIES: GEO

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Diurnal gene expression profiles in mouse brain tissues constituting the central dopamine system

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