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Gene atlasing of digestive and reproductive tissues in Schistosoma mansoni

ABSTRACT: This study provides a detailed transcriptomic analysis of the reproductive tissues (ovary, vitelline and testes) and gastrodermis S. mansoni. The results obtained will help direct future research on the functional aspects of these specific tissues, and will allow the characterisation of currently unannotated genes in S. mansoni

ORGANISM(S): Schistosoma mansoni

PROVIDER: GSE23942 | GEO | 2010/09/03

SECONDARY ACCESSION(S): PRJNA130419

REPOSITORIES: GEO

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Gene atlasing of digestive and reproductive tissues in Schistosoma mansoni

Project description:This study provides a detailed transcriptomic analysis of the reproductive tissues (ovary, vitelline and testes) and gastrodermis S. mansoni. The results obtained will help direct future research on the functional aspects of these specific tissues, and will allow the characterisation of currently unannotated genes in S. mansoni Quantification of gene expression within specific, biologically important tissues of S. mansoni was achieved by a combination of laser microdissection microscopy (LMM) and oligonucleotide microarray analysis. We compared the gene expression profile of the adult female gastrodermis and male and female reproductive tissues with whole worm controls. This is complemented by a set of data from macrodissected samples from different regions of the worm.

2010-09-03 | E-GEOD-23942 | biostudies-arrayexpress

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Preliminaly gene transcriptional profiling of the oesophageal gland of male S. mansoni

Project description:This study provides a transcriptomic analysis of the oesophageal gland of S. mansoni male. The results obtained will help direct future research on the functional aspects of this tissue, and will allow the characterisation of currently unannotated genes in S. mansoni Quantification of gene expression of S. mansoni male oesophageal gland was achieved by a combination of laser microdissection microscopy (LMM) and oligonucleotide microarray analysis. We compared the gene expression profile of the adult male oesophageal glands with whole male worm controls.

2012-12-19 | E-GEOD-42982 | biostudies-arrayexpress

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Gene Atlasing of digestive and reproductive tissues in Schistosoma mansoni.

Project description:BACKGROUND: While considerable genomic and transcriptomic data are available for Schistosoma mansoni, many of its genes lack significant annotation. A transcriptomic study of individual tissues and organs of schistosomes could play an important role in functional annotation of the unknown genes, particularly by providing rapid localisation data and thus giving insight into the potential roles of these molecules in parasite development, reproduction and homeostasis, and in the complex host-parasite interaction. METHODOLOGY/PRINCIPAL FINDINGS: Quantification of gene expression in tissues of S. mansoni was achieved by a combination of laser microdissection microscopy (LMM) and oligonucleotide microarray analysis. We compared the gene expression profile of the adult female gastrodermis and male and female reproductive tissues with whole worm controls. The results revealed a total of 393 genes (contigs) that were up-regulated two-fold or more in the gastrodermis, 4,450 in the ovary, 384 in the vitelline tissues of female parasites, and 2,171 in the testes. We have also supplemented these data with the identification of highly expressed genes in different regions of manually dissected male and female S. mansoni. Though relatively crude, this dissection strategy provides low resolution localisation data for critical regions of the adult parasites that are not amenable to LMM isolation. CONCLUSIONS: This is the first detailed transcriptomic study of the reproductive tissues and gastrodermis of S. mansoni. The results obtained will help direct future research on the functional aspects of these tissues, expediting the characterisation of currently unannotated gene products of S. mansoni and the discovery of new drug and vaccine targets.

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Project description:Transcriptional profiling using two subsequent developmental stages of Schistosoma mansoni (Egg vs. Miracidium; Cercaria vs. 7-days-old Schistosomulum; 7-days-old Schistosomulum vs. Adult worms

2011-04-30 | GSE27026 | GEO

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