Genomics

Dataset Information

0

Histone modification in dendritic cell progenitors and dendritic cells


ABSTRACT: To understand the roles of Irf8 3’ enhancers on Irf8 expression during cDC1 differentiation, we performed Cleavage Under Targets and Tagmentation (CUT&Tag) analysis for H3K27ac of bone marrow cells and splenocytes from wild-type, and the Irf8 enhancer-deficient mice. Phenotypic analysis and integrated analysis of CUT&Tag data with transcriptome data of these mouse mononuclear phagocytic lineage cells revealed that the +56 kb enhancer acts on other 3′ enhancers via an IRF8-dependent TF program and the +32 kb enhancer acts in cis to activate other 3′ enhancers.

ORGANISM(S): Mus musculus

PROVIDER: GSE239738 | GEO | 2024/04/24

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-04-24 | GSE239739 | GEO
2020-12-20 | GSE149757 | GEO
2019-06-23 | GSE132240 | GEO
2020-12-20 | GSE149761 | GEO
2019-06-23 | GSE132239 | GEO
2023-03-15 | GSE218990 | GEO
2023-03-15 | GSE218991 | GEO
2020-11-13 | GSE158327 | GEO
2024-08-18 | GSE270060 | GEO
2022-12-09 | GSE196348 | GEO