Transcriptomics

Dataset Information

0

Gene expression profiling in murine mononuclear phagocyte lineage cells


ABSTRACT: To understand the mechanism underlying monocyte and dendritic cell development through the regulation of Irf8 expression by the 56 kb downstream (+56 kb) Irf8 enhancer, we performed transcriptome analysis of bone marrow cells and splenocytes from wild-type, the Irf8 +56 kb enhancer-deficient, and IRF8-deficient mice. Taken together with the epigenetic profiling of mononuclear phagocyte lineage cells in these mice, the Irf8 +56 kb enhancer-mediated high Irf8 expression in hematopoietic progenitor cells promote type 1 classical dendritic cell (cDC1) differentiation, while low Irf8 expression in progenitors led to Ly6C+ monocyte development.

ORGANISM(S): Mus musculus

PROVIDER: GSE149761 | GEO | 2020/12/20

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-12-20 | GSE149757 | GEO
2020-12-20 | GSE149756 | GEO
2024-04-24 | GSE239739 | GEO
2024-04-24 | GSE239738 | GEO
2023-03-15 | GSE218991 | GEO
2023-03-15 | GSE218990 | GEO
2019-06-23 | GSE132240 | GEO
2019-06-23 | GSE132239 | GEO
2013-01-24 | E-GEOD-38810 | biostudies-arrayexpress
2024-08-18 | GSE270060 | GEO