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ATAC-sequencing of genetically engineered intestinal organoid lines modeling colorectal cancer (CRC) progression

ABSTRACT: To characterize changes in chromatin accessibility acorss the CRC malignancy continum, wild type organoids (WT), ApcKO (A) and ApcKO::KrasG12D::Smad4KO::Trp53KO (AKSP) tumoroids were subjected to bulk ATAC-seq. We then performed differential accessibility analysis using data obtained from ATAC-seq of the indicated organoid lines.

ORGANISM(S): Mus musculus

PROVIDER: GSE239752 | GEO | 2024/10/17

REPOSITORIES: GEO

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