Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Elucidating the role of RXR in driving the OnF porgram along the CRC malignancy contiuum.

ABSTRACT: To investigate the role of RXR during eraly OnF reporgramming, we perturbed the APC/RXR regulatory axis during tumor intiation. To investigate the role of RXR in sustaining the OnF state in advanced CRC, we perturbed its expression in AKSP tumoroids.

ORGANISM(S): Mus musculus

PROVIDER: GSE263045 | GEO | 2024/10/17

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptional profiling of advanced CRC tumoroids (AKSP) follwoing RXR inhbition

Project description:To investigate the role of RXR in regulating the OnF state in advanced CRC, we inhbited its acitvity in AKSP tumoroids.

2024-10-17 | GSE263044 | GEO

Transcriptional profiling of AKSP tumoroids following knockdown of either YAP or FOS.

Project description:To elucidate the role of YAP and FOS in sustaining the OnF state in davnaced CRC, we knocked down either gene in AKSP tumoroids.

2024-10-17 | GSE263055 | GEO

RNA-sequencing of genetically engineered intestinal organoid lines modeling colorectal cancer (CRC) progression

Project description:To characterize the transcriptional changes acorss the CRC malignancy continum, wild type organoids (WT), ApcKO (A) and ApcKO::KrasG12D::Smad4KO::Trp53KO (AKSP) tumoroids were subjected to bulk RNA_seq. We then performed gene expression profiling analysis using data obtained from mRNA-seq of the indicated organoid lines.

2024-10-17 | GSE239754 | GEO

ATAC-sequencing of genetically engineered intestinal organoid lines modeling colorectal cancer (CRC) progression

Project description:To characterize changes in chromatin accessibility acorss the CRC malignancy continum, wild type organoids (WT), ApcKO (A) and ApcKO::KrasG12D::Smad4KO::Trp53KO (AKSP) tumoroids were subjected to bulk ATAC-seq. We then performed differential accessibility analysis using data obtained from ATAC-seq of the indicated organoid lines.

2024-10-17 | GSE239752 | GEO

Investigating the role of YAP and FOS in driving OnF reporgramming during tumor intiation

Project description:To investigate the role of YAP and FOS in early OnF reporgramming, we knocked down either gene during tumor intiation induced by APC depletion.

2024-10-17 | GSE263047 | GEO

Investigating the role of FOS/AP-1 in OnF reprogramming during tumor intiation

Project description:To investigate the role of FOS/AP-1 in early OnF reprogramming, we blocked its activity during tumor intiation by overexpressing a dominant negative form of FOS.

2024-10-17 | GSE263056 | GEO

10X Multiome AKSP

Project description:To characterize transcription factors (TFs) that govern the various cellular states in CRC, AKSP tumoroids were subjected to Mutliome analysis combining s.c ATAC-seq and s.c 3' RNA-seq.

2024-10-17 | GSE237938 | GEO

Transcriptional profiling of single cells from epithelial organoids modelling Intestinal tumorigenesis

Project description:To chart cell state dynamics across the malignancy continuum of colorectal cancer, wild type organoids (WT), ApcKO (A) and ApcKO::KrasG12D::Smad4KO::Trp53KO (AKSP) tumoroids were subjected to single cell RNA-seq.

2024-10-17 | GSE240129 | GEO

Validation of the Oncofetal (OnF) phenotypic reporter

Project description:To test its specificity, VAKSP tumoroids expressing the OnF reporter were sorted based on their GFP expression status. We then performed gene expression profiling analysis using data obtained from mRNA-seq of GFP high and GFP negative VAKPS cells.

2024-10-17 | GSE235205 | GEO

RXR mediated neurogenesis (ChIP-Seq)

Project description:A growing number of pieces of evidence suggest the importance of Retinoid X Receptor (RXR)-mediated pathways in neurogenesis and the dysregulation of this signaling in neurodegenerative disorders, such as Alzheimer`s or Amyotrophic Lateral Sclerosis. The data presented here identify the RAR:RXR and LXR:RXR-mediated transcriptional program in embryonic stem cells, neural progenitors and terminally differentiated neurons.

2017-07-22 | GSE101768 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data