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Effects of TX527, a hypocalcemic vitamin D analog on human activated T lymphocytes

ABSTRACT: Hypocalcemic vitamin D analogs are appealing molecules to exploit the immunomodulatory actions of active vitamin D in vivo. The functional modulation of dendritic cells is regarded as the key mechanism underlying their ability to regulate T cell responses. In contrast, the direct actions of vitamin D and structural analogs on T lymphocytes remain less well characterized. Microarray analysis was performed to gain insight into the direct immunomodulatory actions of TX527, a hypocalcemic vitamin D analog, on human T lymphocytes. Gene expression analysis revealed that TX527 regulated a wide variety of genes involved in different aspects of T cell function, including cellular growth and proliferation, cell death, cellular development, cellular movement and cell-to-cell signalling and interaction.

ORGANISM(S): Homo sapiens

PROVIDER: GSE23984 | GEO | 2010/11/15

SECONDARY ACCESSION(S): PRJNA130479

REPOSITORIES: GEO

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Transcription profiling of human activated T lymphocytes to determine the effects of TX527, a hypocalcemic vitamin D analog

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