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Expression data from wild-type FY4 and the BAS1-deletion strain

ABSTRACT: The impact on mRNA expression of the transcription factors Bas1, Pho2, Gcn4 and Gcr2p was investigated in the corresponding deletion strains during exponential growth in glucose minimal media batch cultures.

ORGANISM(S): Schizosaccharomyces pombe Saccharomyces cerevisiae

PROVIDER: GSE24053 | GEO | 2010/12/01

SECONDARY ACCESSION(S): PRJNA133665

REPOSITORIES: GEO

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Expression data from wild-type FY4 and the GCN4-deletion strain

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Expression data from wild-type FY4 and the BAS1-deletion strain

Project description:The impact on mRNA expression of the transcription factors Bas1, Pho2, Gcn4 and Gcr2p was investigated in the corresponding deletion strains during exponential growth in glucose minimal media batch cultures. All strains were grown in the same media and harvested during exponential growth, at the same cell density, for gene expression analysis. Gene expression analysis of each deletion mutant can be compared relative to the reference strain FY4. Three replicates each strain.

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Expression data from wild-type FY4 and GCR2 deletion strain

Project description:Expression data from wild-type FY4 and GCR2 deletion strain. Impact of the transcription factor Gcr2p on mRNA expression was investigated in the corresponding deletion strain in exponentially growing glucose minimal medium batch cultures. Both streins were grown on glucose minimal medium and harvested during exponential growth for transcript analysis

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Expression data from wild-type FY4 and the TF-KOs BAS1-, PHO2-, GCN4- and GCR2-deletion strains

Project description:Expression data from wild-type FY4 and the TF-KOs BAS1-, PHO2-, GCN4- and GCR2-deletion strains

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Bas1 and Ino4 ChIP-seq

Project description:Meiotic recombination is initiated by developmentally programmed DNA double-strand breaks (DSBs). In S. cerevisiae, the vast majority of DSBs occur in the nucleosome-depleted regions at gene promoters, where transcription factors (TFs) bind. It has been proposed that TF binding can stimulate DSB formation nearby by modulating local chromatin structure. However, a prior study in TF bas1 mutant suggested that the role of TF binding in determining break formation is complex. Here, we examined fine-scale DSB distributions in TF mutant (bas1Δ and ino4Δ) strains. In bas1Δ mutants, 239 out of the 2468 hotspots showed reduced DSB activity, whereas 87 hotspots showed increased DSB activity. Similarly, in ino4Δ mutant, 415 out of the 2468 hotspots showed reduced DSB activity, whereas 322 hotspots showed increased DSB activity. We also mapped Bas1 and Ino4 binding sites in meiosis and found that only a small portion of the affected hotspots contained TF binding sites. This indicates that TF can influence DSB distribution both directly and indirectly. Surprisingly, these DSB changes in TF mutants did not correlate with change in chromatin structure and histone H3K4me3 modification, suggesting that the role of TF on DSB distribution cannot be simply explained by affecting local chromatin status. Four samples total: Bas1-Myc (ChIP and input samples), Ino4-Myc (ChIP and input samples)

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