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YTHDC1 is essential for cardiac development [ATAC-seq]

ABSTRACT: The goal of this study is to investigate how YTHDC1 regulate cardiac development.

ORGANISM(S): Mus musculus

PROVIDER: GSE241270 | GEO | 2024/05/05

REPOSITORIES: GEO

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YTHDC1 is essential for cardiac development

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Project description:Heat shock induces a cell response leading to profound changes in genome expression. Recently, N6-methyladenosine (m6A) RNA modification has been implicated in this response, but with limited information of its role in the heat-induced reprograming of gene expression. Most of m6A molecular and cellular functions rely on m6A readers and the best characterized m6A readers are members of the YTH-domain-containing protein family present from yeast to humans. To investigate the function of the nuclear m6A reader YTHDC1, we characterized its binding partners.

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