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Single cell transcriptomic landscape of pediatric B-cell acute lymphoblastic leukemia: dissection of transcriptional heterogeneity and B-cell developmental state

ABSTRACT: Genomic analyses of bulk ALL samples have improved our understanding of the genetic basis and risk stratification of B-cell acute lymphoblastic leukemia (B-ALL), but do not directly examine intratumor heterogeneity or enable inference of leukemia developmental state and cell of origin. In this study we profiled 89 B-ALL samples by single-cell RNA-seq (scRNA-seq) (10X Genomics 5’v2) to investigate transcriptional heterogeneity and developmental states of leukemic cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE241405 | GEO | 2025/03/07

REPOSITORIES: GEO

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