Genomics

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The synthetic opioid fentanyl increases HIV replication expression in macrophages


ABSTRACT: The illicit use of synthetic opioids such as fentanyl has led to a serious public health crisis in the US. People with opioid use disorder are more likely to contract infections such as HIV and viral hepatitis and experience more severe disease. While several drugs of abuse are known to enhance viral replication and to suppress immunologic responses, the effects of synthetic opioids on HIV pathogenesis have not been investigated thoroughly. Thus, we examined the impact of fentanyl on macrophage cell line U937 and monocyte derived macrophage cells and chemokine receptor expression in vitro.

ORGANISM(S): Homo sapiens

PROVIDER: GSE241769 | GEO | 2024/08/28

REPOSITORIES: GEO

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