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Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes

ABSTRACT: Opioid use disorder (OUD) is a public health crisis currently being exacerbated by increases in use of fentanyl; therefore, the identification of novel biomarkers and treatment strategies is critical. Here, we define how manipulations of the gut microbiome drive fentanyl intake, fentanyl seeking, and alter proteomic plasticity in the nucleus accumbens. These findings establish clear relevance for gut-brain signaling in OUD, and lay foundations for further translational work in this space.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: TuKiet Lam

LAB HEAD: TuKiet Lam

PROVIDER: PXD035810 | Pride | 2024-05-22

REPOSITORIES: Pride

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			Action	DRS
	HFX21-1836_Hofford_101_1.raw	Raw
	HFX21-1840_Hofford_101_2.raw	Raw
	HFX21-1844_Hofford_102_1.raw	Raw
	HFX21-1848_Hofford_102_2.raw	Raw
	HFX21-1852_Hofford_103_1.raw	Raw

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Publications

Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids.

Hofford Rebecca S RS Meckel Katherine R KR Wiser Elizabeth J EJ Wang Weiwei W Sens Jonathon P JP Kim Michelle M Godino Arthur A Lam TuKiet T TT Kiraly Drew D DD

eNeuro 20240215 2

Opioid use disorder (OUD) is a public health crisis currently being exacerbated by increased rates of use and overdose of synthetic opioids, primarily fentanyl. Therefore, the identification of novel biomarkers and treatment strategies to reduce problematic fentanyl use and relapse to fentanyl taking is critical. In recent years, there has been a growing body of work demonstrating that the gut microbiome can serve as a potent modulator of the behavioral and transcriptional responses to both stim ...[more]

PMID: 38164564

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