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Effects of linoleic acid metabolite on liver gene expression in a diet-induced NAFLD/NASH model.

ABSTRACT: To investigate the alterlation of liver gene expression by linoleic acid (LA) metabolite HYA (10-hydroxy-cis-12-octadecenoic acid) in a diet-induced NAFLD/NASH model, we evaluated liver of male C57BL/6J mice fed a nomal diet (ND), a high fat diet (HFD, Control(CT)), HFD supplemented with 1% HYA (HYA), or HFD supplemented with 1% LA (LA) for 26 weeks from 5-week-old. We then performed gene expression profiling analysis using data obtained from RNA-seq of these 4 groups.

ORGANISM(S): Mus musculus

PROVIDER: GSE242881 | GEO | 2023/09/11

REPOSITORIES: GEO

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