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T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis

ABSTRACT: Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease (AD) remains uncertain, despite age being a major risk factor. Using a mouse model of AD, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE243018 | GEO | 2024/05/10

REPOSITORIES: GEO

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T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]

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T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis

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