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T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]

ABSTRACT: T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]

PROVIDER: PRJNA1016407 | ENA |

REPOSITORIES: ENA

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T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]

Project description:Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.

2024-05-14 | GSE243120 | GEO

T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis

Project description:Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease (AD) remains uncertain, despite age being a major risk factor. Using a mouse model of AD, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.

2024-05-10 | GSE243018 | GEO

T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis

Project description:T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis

| PRJNA1015730 | ENA

Perinatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography [MERFISH]

Project description:Perinatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography [MERFISH]

| PRJNA1076924 | ENA

T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

| S-EPMC11303250 | biostudies-literature

MERFISH reveals embryonic endothelial heterogeneity

Project description:MERFISH reveals embryonic endothelial heterogeneity

| PRJNA1038713 | ENA

Perinatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography [MERFISH]

Project description:Preterm infants are at risk for brain injury and long term neurodevelopmental impairment due, in part, to white matter injury following chronic hypoxia exposure. However, the precise molecular mechanisms by which perinatal hypoxia disrupts early neurodevelopment are poorly understood. Here, we constructed a brain-wide map of the regenerative response to newborn brain injury using high resolution imaging-based spatial transcriptomics (MERFISH) to analyze over 1.3 million cells in a mouse model of chronic neonatal hypoxia. We also developed a new method for inferring condition-associated differences in cell type spatial proximity, enabling the identification of niche-specific changes in cellular architecture. We observed significant hypoxia-associated changes in region-specific cell states, cell type composition, and spatial organization. Our findings suggest that perinatal hypoxia disrupts oligodendrocyte formation and crosstalk signaling with other cell types in their niche. Importantly, our analysis of spatially-informed gene expression patterns revealed specific mechanisms of reparative neurogenesis and gliogenesis, and nominated pathways that may impede circuit rewiring following perinatal hypoxia. Altogether, our work provides a comprehensive description of the brain-wide response to newborn brain injury and identifies candidate signaling pathways for functional interrogation.

2024-08-01 | GSE255892 | GEO

Young and Aged Striatal Astrocyte MERFISH Panel

Project description:Given that the striatum is a large, multifunctional nucleus, we next aimed to understand where astrocyte subtypes exist in the striatum at a single-cell resolution using MERFISH. We reproducibly identified the seven astrocyte subtypes, some of which were dorsal (A1, A7), medial (A3, A6) or ventral dominant (A4).

2024-10-03 | GSE262083 | GEO

Spatial Transcriptomics correlated Electron Microscopy [MERFISH]

Project description:Spatial Transcriptomics correlated Electron Microscopy [MERFISH]

| PRJNA836863 | ENA

The transcriptome of central nervous system myelin

Project description:Rapid nerve conduction in the CNS is facilitated by the insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; however, the molecular and cellular basis of myelin dynamics is not well understood. Hypothesizing that only a fraction of all myelin-related mRNAs has been identified so far, we subjected myelin biochemically purified from mouse brains at various ages to RNA sequencing. We find a surprisingly large pool of transcripts abundant and/or enriched in myelin. Furthermore, a comprehensive analysis showed that the myelin transcriptome is closely related to the myelin proteome but clearly distinct from the transcriptomes of oligodendrocytes and brain tissues, suggesting that the incorporation of mRNAs into the myelin compartment is highly selective. The mRNA-pool in myelin displays maturation-dependent dynamic changes of composition, abundance, and functional associations; however ageing-dependent changes after 6 months of age were minor. We suggest that this transcript pool provides a basis for the local modulation of myelin turnover and adaptation, i.e. in the individual internode. A light-weight membrane fraction enriched for myelin was purified from mouse brains as described previously (Jahn et al., Neuromethods, 2013). For RNA-Seq, RNA was isolated from myelin of mice from indicated ages.

2016-06-24 | E-GEOD-78151 | biostudies-arrayexpress

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