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IMM_Cleveland LiXX_EAE-Th1 or Th17_Act1 ko mouse_CNS_exp1

ABSTRACT: The goal of these studies is to define the molecular signatures of TH1-induced EAE and TH17-induced EAE through adoptive transfer. We will also define the role of IL-17 signaling in the pathology by comparing cells derived from wild type mice to those derived from mice lacking Act1, a key adaptor required for IL-17 dependent signaling. Brains and spinal cords from animals at peak of disease will be profiled.

ORGANISM(S): Mus musculus

PROVIDER: GSE97035 | GEO | 2017/03/28

SECONDARY ACCESSION(S): PRJNA380640

REPOSITORIES: GEO

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