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Gene expression data from liver of rat fed a high-fat diet and high-fructose water without/with Eucommia ulmoides leaves

ABSTRACT: To investigate effects of intake of Eucommia ulmoides leaves on hyperlipidemia, we performed gene expression profiling on rat liver by microarray analysis. Microarray analysis revealed that Eucommia ulmoides leaves up-regulated the gene expression involved in alpha-, beta-, and omega-oxidation of fatty acids, mainly relating to peroxisome proliferator-activated receptor signaling pathway.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE24377 | GEO | 2011/08/22

SECONDARY ACCESSION(S): PRJNA132859

REPOSITORIES: GEO

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Gene expression data from liver of rat fed a high-fat diet and high-fructose water without/with Eucommia ulmoides leaves

Project description:To investigate effects of intake of Eucommia ulmoides leaves on hyperlipidemia, we performed gene expression profiling on rat liver by microarray analysis. Microarray analysis revealed that Eucommia ulmoides leaves up-regulated the gene expression involved in alpha-, beta-, and omega-oxidation of fatty acids, mainly relating to peroxisome proliferator-activated receptor signaling pathway. Rats were fed a high-fat diet and high-fructose water without/with orally administration of Eucommia ulmoides leaves for 5 weeks. Livers were taken for RNA extraction and hybridization on Agilent microarrays.

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