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Identification and targeting of extremely high-risk gamma delta T-ALL in children [HiChIP, ChIP and ATAC]

ABSTRACT: STAG2/LMO2 subtype in T-ALL was investigated through integrative genomic analysis. H3K27ac HiChIP was used to investigate the impact of LMO2::STAG2 translocations in MOLT-14 and PER-117 cell lines. ChIP-seq was used to explore the effects of STAG2 inactivation by using gene-edited MOLT-14 and PF382 cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE243772 | GEO | 2024/03/01

REPOSITORIES: GEO

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