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Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane

ABSTRACT: Although sevoflurane is one of the most commonly used inhalational anesthetic agent, the popularity of desflurane is increasing to a similar level. The main beneficial property of desflurane is the relatively fast emergence of the patient from the anesthetic state after halting its supply compared with anesthesia using other anesthetic agents. However, there has been no comprehensive comparison of the effects of these two anesthetic agents on alterations in liver gene expression profiles in animals, including humans, to assess the kinds of biological abnormalities/changes and their levels in the host. Thus, we compared alterations in the global gene expression profiles in the livers of rats subjected to inhalational anesthesia by sevoflurane or desflurane by a next-generation sequencing method.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE244436 | GEO | 2024/02/21

REPOSITORIES: GEO

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Comparison of global gene expression profile associated with inhalation anesthesia between sevoflurane and desflurane

Project description:Comparative gene expression profiling analysis of RNA-seq data for livers from rats subjected to inhalational anesthesia with either sevoflurane or desflurane and their controls that were treated with sevoflurane or desflurane only briefly until the loss of their consciousness.

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Astrocytes modulate a specific paraventricular thalamus-prefrontal cortex projection to enhance consciousness recovery from sevoflurane anesthesia in mice

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Expression data from sevoflurane anesthesia treated rat

Project description:Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders (PNCD), especially in anesthesia related brain dysfunction, remains unknown. We explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia with microarrays.

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Expression data from sevoflurane anesthesia treated rat

Project description:Expression data from sevoflurane anesthesia treated rat

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2021-05-31 | E-MTAB-10510 | biostudies-arrayexpress

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