Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

KDM6A Regulates Immunogenicity of Multiple Myeloma (ATAC-seq)

ABSTRACT: We created isogenic mutiple myeloma cell lines disrupted for KDM6A using CRISPR-mediated editing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE244509 | GEO | 2024/10/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

KDM6A Regulates Immunogenicity of Multiple Myeloma (RNA-seq)

Project description:We created isogenic mutiple myeloma and mouse embryonic fibroblast cell lines disrupted for KDM6A using CRISPR editing and Cre-mediated deletion.

2024-10-01 | GSE244511 | GEO

KDM6A Regulates Immunogenicity of Multiple Myeloma (ChIP-seq)

Project description:We created isogenic mutiple myeloma and mouse embryonic fibroblast cell lines disrupted for KDM6A using CRISPR editing and Cre-mediated deletion. To detect KDM6A we inserted a dual HA tag sequence into the C-terminal of KDM6A by CRISPR-mediated editing. We also created one isogenic cell line harboring a jmjD-dead KDM6A where 2 amino acids essential for KDM6A enzymatic activity, H1146 and E1148 , were replaced with alanine residues

2024-10-01 | GSE244510 | GEO

KDM6A Regulates Immunogenicity of Multiple Myeloma

Project description:KDM6A Regulates Immunogenicity of Multiple Myeloma

| PRJNA1023289 | ENA

KDM6A Regulates Immunogenicity of Multiple Myeloma (ChIP-seq)

Project description:KDM6A Regulates Immunogenicity of Multiple Myeloma (ChIP-seq)

| PRJNA1023291 | ENA

KDM6A Regulates Immunogenicity of Multiple Myeloma (ATAC-seq)

Project description:KDM6A Regulates Immunogenicity of Multiple Myeloma (ATAC-seq)

| PRJNA1023292 | ENA

KDM6A Regulates Immunogenicity of Multiple Myeloma (RNA-seq)

Project description:KDM6A Regulates Immunogenicity of Multiple Myeloma (RNA-seq)

| PRJNA1023293 | ENA

KDM6A Regulates Immunogenicity of Multiple Myeloma

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-01 | GSE244512 | GEO

Transcriptome analysis of CHEK1 overexpression (AC or HC) VS control (A or H) and CHEK1 knockdown (AK_D or HK_D) VS control (AK or HK) in Mutiple Myeloma.

Project description:Transcriptome sequencing was used to analyze changes in related signaling pathways and gene expression in Mutiple Myeloma cells when CHEK1 was overexptressed or knocked down.

2020-07-11 | GSE154164 | GEO

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

Project description:In this project we analyze the transcriptome of the human multiple myeloma isogenic cell lines ARP-1 (UTX wild-type) and ARD (UTX null). The transcriptome is studied at baseline, upon restoration of UTX levels in ARD cells for 3 and 6 days, and upon treatment of the cell lines with the EZH2 inhibitor GSK343. Moreover, we analyzed the transcriptome of a ARD resistant cell line that we generated.

2017-10-25 | GSE103567 | GEO

Protein and histone binding profiles from mouse ES cells during differentiation and after Kdm6a RNAi treatment.

Project description:Here we show binding and occupancy profiles for KDM6A, H3K27me3 and H3K4me3 to address the epigenetic regulation of a subset of Rhox genes, Rhox6 and 9, in female and male ES cells during differentiation. To further address a functional role for KDM6A in the epigenetic regulation of Rhox6 and 9, binding profiles for female ES cells treated with a control siRNA and siRNA specific for Kdm6a are shown. We report that two members of the Rhox cluster, Rhox6 and 9, are regulated by de-methylation of histone H3 at lysine 27 by KDM6A, a histone demethylase with female-biased expression. Our results are consistent with other homeobox genes in that Rhox6 and 9 are in bivalent domains prior to embryonic stem cell differentiation and thus poised for activation. In female mouse ES cells KDM6A is specifically recruited to Rhox6 and 9 for gene activation, a process inhibited by Kdm6a knockdown. In contrast, KDM6A occupancy at Rhox6 and 9 is low in male ES cells and knockdown has no effect on expression. Our study implicates Kdm6a, a gene that escapes X inactivation, in the regulation of genes important in reproduction, suggesting that KDM6A may play a role in the etiology of developmental and reproduction-related effects of X chromosome anomalies. ChIP-chip was used to analyze the binding profiles of KDM6A, H3K27me3, and H3K4me3 during differentiation in female and male ES cells. Additionally, ChiP-chip of KDM6A binding in control treated and siRNA treated ES cells is presented.

2013-03-22 | E-GEOD-45390 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data