Sub-chronic peripheral CB1R blockade enhances cognitive performance and induces hippocampal synaptic plasticity changes in mice
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ABSTRACT: Using RNA sequencing, we perform gene expression profile of five male mice treated with vehicle and five male mice sub-chronically treated with AM6545 at a dose of 1 mg/kg. To evaluate hippocampal modifications promoted by peripheral CB1R modulation, we analyze at transcript level hippocampal synaptoneurosomes fractions. This analysis revealed changes in the transcript usage of N-methyl-D-aspartate (NMDA) receptor 1 isoforms in AM6545 treated mice compared with vehicle-treated ones.
ORGANISM(S): Mus musculus
PROVIDER: GSE245307 | GEO | 2023/12/01
REPOSITORIES: GEO
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