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Sub-chronic AM6545 administration enhances cognitive performance and induces hippocampal synaptic plasticity changes in female mice

ABSTRACT: Using RNA sequencing, we perform gene expression profile of three female mice treated with vehicle and four female mice sub-chronically treated with AM6545 at a dose of 1 mg/kg. To evaluate hippocampal modifications promoted by peripheral CB1R modulation, we analyze at transcript level hippocampal synaptoneurosomes fractions. This analysis revealed changes in the transcript expression of genes associated to mitochondrial processes and synaptic development.

ORGANISM(S): Mus musculus

PROVIDER: GSE268761 | GEO | 2025/01/30

REPOSITORIES: GEO

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Sub-chronic AM6545 administration enhances cognitive performance and induces hippocampal synaptic plasticity changes in female mice

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