Transcriptomics

Dataset Information

0

Detection of APOBEC3B-mediated RNA editing sites in T-47D cells [RNA-seq]


ABSTRACT: RNA editing is a crucial post-transcriptional process that diversifies proteomic outcomes and influences gene expression. Particularly, the APOBEC3 family has emerged as a significant player in this mechanism, with APOBEC3A (A3A) showing notable roles in immune response and stress conditions. APOBEC3B (A3B), another family member, has garnered attention for its potential role in breast cancer genomic mutations. In this study, we employ an inducible expression cell model and a novel methodology for identifying differential variants in RNA (DVRs) to map A3B-mediated RNA editing sites in a breast cancer cell model. Our findings indicate that A3B engages in selective RNA editing and targets NEAT1 and MALAT1 long non-coding RNAs. Notably, the binding of these RNAs sequesters A3B’s catalytic activity, and thereby affects A3A’s activity through a feedback loop.

ORGANISM(S): Homo sapiens

PROVIDER: GSE245700 | GEO | 2024/08/14

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-08-14 | GSE245701 | GEO
2023-06-10 | GSE148581 | GEO
2021-07-02 | PXD024191 | Pride
2016-06-30 | GSE78710 | GEO
2016-06-30 | E-GEOD-78710 | biostudies-arrayexpress
2020-10-19 | PXD020473 | Pride
2015-09-07 | E-GEOD-57426 | biostudies-arrayexpress
2015-09-30 | GSE56979 | GEO
2015-09-07 | GSE57426 | GEO
| PRJNA1029590 | ENA