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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE246310 | GEO | 2024/12/31

REPOSITORIES: GEO

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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [RNA-seq]

Project description:In this study, the retinoid and vitamin D pathways were investigated in PMA-differentiated THP-1 cells treated with or without the RARa agonist, AM580, and/or the VDR agonist, 1,25-dihydroxyvitamin D3 (1,25-vitD or calcitriol), using global approaches. Binding regions of RARa and VDR were determined in PMA-differentiated THP-1 cells using chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq). The gene sets regulated by AM580 and/or 1,25-vitD were identified by RNA-sequencing (RNA-seq). The activity of the regulatory regions was determined and chromatin openness was measured using assay for transposase-accessible chromatin with sequencing (ATAC-seq).

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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ChIP-seq]

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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ATAC-seq]

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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells.

Project description:Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells.

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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [RNA-seq]

Project description:Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [RNA-seq]

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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ATAC-seq]

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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ChIP-seq]

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