Transcriptomics

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Transcriptomic profiling in NAT10 knockdown acute myeloid leukemia cells


ABSTRACT: RNA modification represents an important post-transcriptional regulatory mechanism in acute myeloid leukemia (AML), however the function and mechanism of RNA acetylation ac4C in AML remains elusive. Here, we report that NAT10, as the ac4C writing enzyme, plays a critical oncogenic function in AML and represents a promising therapeutic target for AML. To determine the impact of NAT10-mediated ac4C on gene expression, we conducted high throughput RNA-sequencing (RNA-seq) in NAT10-knockdown and control MOLM13 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE246503 | GEO | 2024/08/26

REPOSITORIES: GEO

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