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Type III interferons induce pyroptosis in gut epithelial cells and delay tissue restitution upon acute intestinal injury.

ABSTRACT: To determine the transcriptional programs initiated by IFN-λ to delay tissue restitution, we isolated intestinal crypts from the small intestine of VilCREIfnlr1fl/fl mice or WT littermates that have been irradiated and performed targeted transcriptomics analysis

ORGANISM(S): Mus musculus

PROVIDER: GSE247149 | GEO | 2024/04/01

REPOSITORIES: GEO

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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

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