Genomics

Dataset Information

0

MiRNA expression profiles in productively HIV-1 infected and bystander primary human CD4+ T-cells


ABSTRACT: CD4+ T-cells are the main target of HIV-1 and several host factors can positively or negatively modulate HIV-1 infection of these cells. MiRNAs aresmall regulatory RNAs that are involved in the regulation of basic cellular functions. They are also increasingly recognized as host factors regulatingHIV-1 infection, replication and persistence. In order to identify miRNAs involved in HIV-1 infection of CD4+ T-cells, we performed globaltranscriptomic analyses of productively infected and HIV-1 exposed but non infected bystander CD4+ T-cells and compared their MIRNA profiles with uninfected cells. Theseanalyses were performed in CD4+T-cells isolated from 3 different healthy blood donors. Both miRNA and mRNA expression profiles were compared. Our results show that bystander and uninfected CD4+ T-cells do not display important differences in their miRNA expression profiles even though their respectivemRNA expression profiles were markedly different. In contrast, both mRNA and miRNA expressionprofiles from productively infected CD4+ T-cells were significantly different from those of uninfected cells. Overall, these results suggest that HIV-1infection impacts the miRNA expression profile of primary CD4+ T-cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE247194 | GEO | 2024/08/02

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-08-02 | GSE247191 | GEO
2017-09-11 | GSE103394 | GEO
2007-11-11 | E-GEOD-6740 | biostudies-arrayexpress
2021-07-21 | GSE180273 | GEO
2007-02-23 | GSE6740 | GEO
2019-01-22 | PXD005810 | Pride
2023-01-16 | GSE143942 | GEO
2018-04-02 | MSV000082229 | MassIVE
2011-11-08 | E-GEOD-33514 | biostudies-arrayexpress
2023-11-27 | GSE241723 | GEO