Dataset Information

Dynamics of Proteo-Transcriptomic Response to HIV-1 Infection

ABSTRACT: We have investigated the dynamic host response to HIV-1 infection by systematically measuring transcriptome, proteome and phosphoproteome expression changes in infected and uninfected SupT1 CD4+ T cells at 5 time-points throughout the HIV-1 replication cycle (from 2h to 24h).

OTHER RELATED OMICS DATASETS IN: GSE100587

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human) Human Immunodeficiency Virus Type 1 3916-cro

TISSUE(S): T Cell, Cell Culture

DISEASE(S): Human Immunodeficiency Virus Infectious Disease

SUBMITTER: Manfredo Quadroni

LAB HEAD: Manfredo Quadroni

PROVIDER: PXD005810 | Pride | 2019-01-22

REPOSITORIES: Pride

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Publications

Proteo-Transcriptomic Dynamics of Cellular Response to HIV-1 Infection.

Golumbeanu Monica M Desfarges Sébastien S Hernandez Céline C Quadroni Manfredo M Rato Sylvie S Mohammadi Pejman P Telenti Amalio A Beerenwinkel Niko N Ciuffi Angela A

Scientific reports 20190118 1

Throughout the HIV-1 replication cycle, complex host-pathogen interactions take place in the infected cell, leading to the production of new virions. The virus modulates the host cellular machinery in order to support its life cycle, while counteracting intracellular defense mechanisms. We investigated the dynamic host response to HIV-1 infection by systematically measuring transcriptomic, proteomic, and phosphoproteomic expression changes in infected and uninfected SupT1 CD4+ T cells at five ti ...[more]

PMID: 30659199

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