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Effect of HDAC1/2 Inhibitor compound 60 (Cmpd60) on multiple organ systems in aged Mice

ABSTRACT: In the current work, we performed multiple in silico drug screens using transcriptional profiles of 2837 small molecules testing their ability to mimic known genetic longevity interventions. We identified one compound that was most commonly found to mimic the transcriptional profile of the genetic longevity interventions. This benzamide-based small molecule, termed compound 60 (Cmpd60; aka Merck60 or BRD 692), is a selective histone deacetylase 1 and 2 (HDAC1/2) inhibitor. Here, we used a combination of molecular, phenotypic, and bioinformatic analyses in multiple disease cell models and mouse models for age-related disease to establish if Cmpd60 acts as a geroprotector.

ORGANISM(S): Mus musculus

PROVIDER: GSE247457 | GEO | 2023/11/13

REPOSITORIES: GEO

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