Metabolomics

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Transcriptional memory of dFOXO activation in youth curtails later-life mortality


ABSTRACT: Identifying processes occurring in early life affect subsequent life and health span is an urgent aim to improve human health. In this study, we identified a novel mechanism of dFOXO in longevity determination in Drosophila. We found that early adulthood induction of dFOXO is sufficient to reduce mortality in old age through different pathways than chronic dFOXO. We showed that dFOXO requires specific ATP-dependent chromatin modifiers to extend lifespan, and we could mimic this lifespan extension by modulating dFOXO’s targets in later life. Furthermore, dFOXO in early life induces a specific transcriptional programme that counteracts the natural transcriptomic changes occurring with age. Our findings provide a better understanding of transcriptional mechanisms related to longevity and opens new avenues for possible time-restricted interventions to improve human health in the future.

INSTRUMENT(S): Liquid Chromatography MS - alternating - hilic

SUBMITTER: Guillermo Martinez Corrales 

PROVIDER: MTBLS3251 | MetaboLights | 2022-09-28

REPOSITORIES: MetaboLights

Dataset's files

Source:
Action DRS
MTBLS3251 Other
FILES Other
a_MTBLS3251_LC-MS_alternating_hilic_metabolite_profiling.txt Txt
files-all.json Other
i_Investigation.txt Txt
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