Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Silvia Stojanov
PROVIDER: E-GEOD-17732 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Stojanov Silvia S Lapidus Sivia S Chitkara Puja P Feder Henry H Salazar Juan C JC Fleisher Thomas A TA Brown Margaret R MR Edwards Kathryn M KM Ward Michael M MM Colbert Robert A RA Sun Hong-Wei HW Wood Geryl M GM Barham Beverly K BK Jones Anne A Aksentijevich Ivona I Goldbach-Mansky Raphaela R Athreya Balu B Barron Karyl S KS Kastner Daniel L DL
Proceedings of the National Academy of Sciences of the United States of America 20110408 17
The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever disease in children. However, the pathogenesis is unknown. Using a systems biology approach we analyzed blood samples from PFAPA patients whose genetic testing excluded hereditary periodic fevers (HPFs), and from healthy children and pediatric HPF patients. Gene expression profiling could clearly distinguish PFAPA flares from asymptomatic intervals, HPF flares, and he ...[more]