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Type 2-polarized memory B cells hold allergen-specific IgE memory

ABSTRACT: Allergen-specific IgE antibodies mediate allergic pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. We report a population of type 2 polarized MBCs defined as CD23hi, IL-4Rαhi, CD32low at the transcriptional and surface protein levels.

ORGANISM(S): Homo sapiens

PROVIDER: GSE248256 | GEO | 2023/11/25

REPOSITORIES: GEO

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Type 2-polarized memory B cells hold allergen-specific IgE memory

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