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Paternal methamphetamine exposure differentially affects first and second generations in mice

ABSTRACT: To determine whether paternal methamphetamine exposure alters the development, behavior and gene expression of first (F1) and second (F2) generations. We administrated methamphetamine (5 mg/kg) or saline (10 ml/kg) to sire (F0) and performed gene expression profiling analysis using data obtained from RNA-seq of striatum of 7-week-old male F1 mice. Male F1 mice were mated with untreated female mice to obtain F2 mice. Male F1 mice were mated with female mice to obtain F2 mice. RNA-seq of striatum of 7-week-old male F2 mice was also analyzed in the same way.

ORGANISM(S): Mus musculus

PROVIDER: GSE248542 | GEO | 2024/08/08

REPOSITORIES: GEO

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