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Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Arctium lappa

PROVIDER: GSE248827 | GEO | 2024/05/01

REPOSITORIES: GEO

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Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF [II]

Project description:The incidence of type 2 diabetes (T2DM) induced by obesity is rapidly increasing. Although there are many drugs developed for type 2 diabetes, but the anti-diabetic effect of homology of medicine and food is also very popular with the majority of people. Burdock is one such food, but the molecular mechanism of anti-diabetic effect is unclear, limiting its further promotion. In recent years, studies have shown that plant mirnas can regulate host gene expression through dietary absorption, so plant miRNAs have become one of the main active ingredients in traditional Chinese medicine. Here, we report that miR8175, a plant miRNA from burdock root, has effective antidiabetic activity. miR8175 is highly enriched in burdock decoction. After administration of burdock decoction or synthetic miR8175 by gavage, significantly elevated levels of miR8175 in mouse serum and liver can be observed. Furthermore, both burdock decoction and miR8175 can significantly improve the impaired glucose metabolism of diabetic mice induced by a high-fat diet (HFD). Our results demonstrate that burdock decoction and miR8175 enhance the insulin sensitivity of the hepatic insulin signaling pathway by targeting PTPRF and PTP1B, which may be the reason for the improvement in metabolism.

2024-05-01 | GSE248826 | GEO

Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF [I]

2024-05-01 | GSE247265 | GEO

Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF

Project description:Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF

| PRJNA1046067 | ENA

Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF [I]

Project description:Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF [I]

| PRJNA1037016 | ENA

Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF [II]

Project description:Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF [II]

| PRJNA1046073 | ENA

Hsp90? knockdown in DIO mice reverses insulin resistance and improves glucose tolerance.

Project description:Background:Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role in regulating insulin signaling and glucose metabolism. Methods:In a diet-induced obese (DIO) mouse model of diabetes, expression of various Hsp90 isoforms in skeletal tissue was examined. Subsequent experiments characterized the role of Hsp90ab1 isoform in glucose metabolism and insulin signaling in primary human skeletal muscle myoblasts (HSMM) and a DIO mouse model. Results:In DIO mice Hsp90ab1 mRNA was upregulated in skeletal muscle compared to lean mice and knockdown using anti-sense oligonucleotide (ASO) resulted in reduced expression in skeletal muscle that was associated with improved glucose tolerance, reduced fed glucose and fed insulin levels compared to DIO mice that were treated with a negative control oligonucleotide. In addition, knockdown of HSP90ab1 in DIO mice was associated with reduced pyruvate dehydrogenase kinase-4 mRNA and phosphorylation of the muscle pyruvate dehydrogenase complex (at serine 232, 293 and 300), but increased phosphofructokinase 1, glycogen synthase 1 and long-chain specific acyl-CoA dehydrogenase mRNA. In HSMM, siRNA knockdown of Hsp90ab1 induced an increase in substrate metabolism, mitochondrial respiration capacity, and insulin sensitivity, providing further evidence for the role of Hsp90ab1 in metabolism. Conclusions:The data support a novel role for Hsp90ab1 in arbitrating skeletal muscle plasticity via modulation of substrate utilization including glucose and fatty acids in normal and disease conditions. Hsp90ab1 represents a novel target for potential treatment of metabolic disease including diabetes.

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Cross-species Gene Expression Analysis Identifies a Novel Set of Genes Implicated in Human Insulin Sensitivity

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-12-09 | E-GEOD-73037 | biostudies-arrayexpress

Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity

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2021-06-24 | GSE178561 | GEO

Inhibiting phosphatidylcholine remodeling in adipose tissue increases insulin sensitivity

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Dynamic changes of muscle insulin sensitivity after metabolic surgery

Project description:This SuperSeries is composed of the SubSeries listed below.