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Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration

ABSTRACT: Expression analysis of migrating and non-migrating mesenchymal stromal cells (MSC) in fetal bone marrow Keywords: fetal bone marrow, mesenchymal stromal cells, migration, gene expression, genomics

ORGANISM(S): Homo sapiens

PROVIDER: GSE24892 | GEO | 2011/10/24

SECONDARY ACCESSION(S): PRJNA132189

REPOSITORIES: GEO

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Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration

Project description:Expression analysis of migrating and non-migrating mesenchymal stromal cells (MSC) in fetal bone marrow Keywords: fetal bone marrow, mesenchymal stromal cells, migration, gene expression, genomics Three biological replates for both migrating and non-migrating mesenchymal stromal cells (MSC) in fetal bone marrow

2011-10-23 | E-GEOD-24892 | biostudies-arrayexpress

Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration.

Project description:Detailed understanding of mesenchymal stromal cells (MSC) migration is imperative for future cellular therapies. To identify genes involved in the process of MSC migration, we generated gene expression profiles of migrating and nonmigrating fetal bone marrow MSC (FBMSC). Only 12 genes showed differential expression in migrating versus nonmigrating FBMSC. The nuclear receptors Nur77 and Nurr1 showed the highest expression in migratory MSC. Nur77 and Nurr1 are members of NR4A nuclear orphan receptor family, and we found that their expression is rapidly increased upon exposure of FBMSC to the migratory stimuli stromal-derived factor-1? (SDF-1?) and platelet-derived growth factor-BB. Lentiviral expression of Nur77 or Nurr1 resulted in enhanced migration of FBMSC toward SDF-1? compared with mock-transduced FBMSC. Analysis of the cell cycle, known to be involved in MSC migration, revealed that expression of Nur77 and Nurr1 decreases the proportion of cells in S-phase compared with control cells. Further, gain-of-function experiments showed increased hepatocyte growth factor expression and interleukin (IL)-6 and IL-8 production in MSC. Despite the altered cytokine profile, FBMSC expressing Nur77 or Nurr1 maintained the capacity to inhibit T-cell proliferation in a mixed lymphocyte reaction. Our results demonstrate that Nur77 and Nurr1 promote FBMSC migration. Modulation of Nur77 and Nurr1 activity may therefore offer perspectives to enhance the migratory potential of FBMSC which may specifically regulate the local immune response.

| S-EPMC3258434 | biostudies-literature

Single cell RNAseq analysis of fetal perichondrium-derived bone marrow mesenchymal stromal cells

Project description:We revealed a single cell transcriptional landscape of bone marrow mesenchymal stromal cells derived from the fetal perichondrium.

2019-02-26 | GSE126967 | GEO

Single cell RNAseq analysis of fetal growth plate-derived bone marrow mesenchymal stromal cells

Project description:We revealed a single cell transcriptional landscape of bone marrow mesenchymal stromal cells derived from the fetal growth plate cartilage

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Single cell RNA-sequencing of murine endothelial and stromal populations at embryonic day 17 (E17)

Project description:The origin of bone marrow stromal cells (BMSCs) is not completely understood. We have identified a rare population of cells with a transcriptional profile consistent with endothelial to mesenchymal transition (Endo-MT) in human fetal development. Therefore, we hypothesized that Endo-MT contributes to bone marrow niche formation in mammals. Here, we sought to determine whether Endo-MT cells could be identified in murine bone marrow during embryonic development. We isolated bone marrow and collagenased bone fraction from long bones of 9 fetuses at embryonic day 17 (E17) and FACS purified endothelial cells and BMSCs for single cell RNA sequencing.

2021-01-21 | E-MTAB-9994 | biostudies-arrayexpress

Signature of mesenchymal cell lines

Project description:We have analysed tes adipocytic, osteoblastic, chondrocytic and vascular smooth muscle differentiation of the stromal potential of 5 mouse mesenchymal lines derived from hematopoietic sites (bone marrow and fetal liver). The sole line, AFT024, that provide both quadripoential and capable of maintening hematopoiesis in vitro, has served as reference for genomic studies aimed at establishing the signature of the multipotential stromal mesenchymal stem cell (MSC). Keywords: molecular signature of MSC

2006-07-01 | GSE4491 | GEO

Single cell RNAseq analysis of fetal perichondrium-derived bone marrow mesenchymal stromal cells

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Single cell profiling of bone marrow adipocytes and bone marrow stromal cells from irradiated mice.

Project description:In order to comprehensively characterize bone marrow mesenchymal cells after myeloablation, single-nuclei RNA sequencing was performed on bone marrow adipocytes and bone marrow stromal cells isolated from sublethally-irradiated mice.

2023-07-31 | GSE227255 | GEO

TGF-β signaling plays an essential role in the lineage specification of mesenchymal stem/progenitor cells in fetal bone marrow

Project description:TGF-β regulates fetale bone marrow niche emergence. Abrogating TGF-β signaling in mesenchymal cells during development results in a marked expansion of adipocytes and CAR cells in the bone marrow, while osteoblasts are reduced. RNA expression data from Osx-Cre targeted mesenchymal stromal cells obtained from E16.5 mouse hindlimbs of transgenic mice lacking Tgfbr2 in mesenchymal stromal cells or littermate controls.

2019-05-15 | GSE131219 | GEO

Myelodysplastic Syndrome haematopoietic Stem and Progenitor Cells manuplate bone marrow mesenchymal stromal cells for their advantage

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