Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from carotid body glomus cells and neuroblasts, from young adult rats (9-11 weeks of age)

ABSTRACT: The carotid body is a peripheral chemoreceptor organ containing a neurogenic niche with stem cells and immature neuronal cells that convert into new neurons (glomus cells) upon activation by hypoxia. We have used microarray to compare the gene expression programs of glomus cells and neuroblasts, both in normoxic and hypoxic (3 days) conditions, to highlight the molecular mechanisms underlying fast neurogenesis

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE249594 | GEO | 2023/12/17

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single cell transcriptome analysis of mouse carotid body glomus cells

Project description:The carotid body (CB) is a major arterial chemoreceptor containing glomus cells whose activities are regulated by changes in arterial blood contents including oxygen. We employed the single cell RNASeq method by performing next-generation sequencing on single glomus cellderived cDNAs to eliminate contamination of genes derived from other cell types present in the CB. This study has generated a CB expression profile containing novel glomus cell specific genes. The wealth of information provided through this study offers a valuable foundation for identifying molecules functioning in the CB.

2016-03-15 | GSE76579 | GEO

Single cell transcriptome analysis of mouse carotid body glomus cells

Project description:The carotid body (CB) is a major arterial chemoreceptor containing glomus cells whose activities are regulated by changes in arterial blood contents including oxygen. We employed the single cell RNAÂSeq method by performing next-generation sequencing on single glomus cellÂderived cDNAs to eliminate contamination of genes derived from other cell types present in the CB. This study has generated a CB expression profile containing novel glomus cell specific genes. The wealth of information provided through this study offers a valuable foundation for identifying molecules functioning in the CB. 8 single CB glomus cells that were confirmed expressing tyrosine hydroxylase (Th), ubiquitin carboxyl-terminal esterase L1 (Uchl1) and potassium channel subfamily K member 3 (Kcnk3) were harvested from P4-5 wild type mice and subjected to single-cell RNA-Seq

2016-03-15 | E-GEOD-76579 | biostudies-arrayexpress

Expression data from carotid body glomus cells and neuroblasts, from young adult rats (9-11 weeks of age)

Project description:Expression data from carotid body glomus cells and neuroblasts, from young adult rats (9-11 weeks of age)

| PRJNA1049787 | ENA

Single cell transcriptome analysis of mouse carotid body glomus cells

Project description:Single cell transcriptome analysis of mouse carotid body glomus cells

| PRJNA308083 | ENA

Comparative analysis of transcriptomes from the carotid body, adrenal medulla, and superior cervical ganglion of adult mice

Project description:Acute O2 sensing is a fundamental property of cells in the peripheral chemoreceptors, e.g. glomus cells in the carotid body (CB) and chromaffin cells in the adrenal medulla (AM), and is necessary for adaptation to hypoxia. The mechanisms underlying the detection of changes in O2 tension by these cells are still poorly understood. Recently, we suggested that CB glomus cells have specific metabolic features that favour their sensitivity to hypoxia (Fernandez-Aguera et al, 2015, Cell Metab.). To investigate the metabolic profile characteristic of acute O2-sensing cells, we used adult mice to compare the transcriptomes of three organs derived from common sympathoadrenal progenitors, but exhibiting variable responsiveness to acute hypoxia: CB and AM which are O2-sensitive (CB > AM) and superior cervical ganglion (SCG), which are practically O2-insensitive. Our data support the concept that responsiveness to acute hypoxia depends on a “signature metabolic profile” in peripheral chemoreceptor cells.

2017-09-08 | GSE99593 | GEO

Expression profile of mouse carotid body and adrenal medulla [Affymetrix]

Project description:The carotid body is a chemoreceptor that senses decreases in blood oxygen to increase breathing in hypoxia. To look for candidate oxygen sensors in the carotid body, we compared the gene expression of the carotid body to the adrenal medulla, a similar tissue that does not have oxygen sensitivity in adults.

2015-11-11 | GSE72133 | GEO

Expression profile of mouse carotid body and adrenal medulla [RNA-Seq]

2015-11-11 | GSE72165 | GEO

Expression profile of mouse carotid body and adrenal medulla [RNA-Seq]

2015-11-11 | E-GEOD-72165 | biostudies-arrayexpress

Expression profile of mouse carotid body and adrenal medulla [Affymetrix]

2015-11-11 | E-GEOD-72133 | biostudies-arrayexpress

Glomus

Project description:Glomus overview

| PRJNA187012 | ENA