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Cellular landscapes of osteogenically differentiated valvular interstitial cells stimulated with XCT790-loaded nanoparticles

ABSTRACT: The pathogenesis of calcific aortic valve disease (CAVD) is unknown. XCT790 is a specific inhibitor of estrogen-associated receptor alpha (ERR-alpha) that inhibits valve calcification in mouse models. Here, we designed a nanocarrier targeting osteoblast-differentiated valve interstitial cells (VICs) for targeted delivery of XCT790 to the calcified area. We stimulated osteogenic differentiated VICs with this targeting nanoparticle, and performed RNA-seq to assess transcriptional alterations of VICs and explore specific mechanisms.

ORGANISM(S): Homo sapiens

PROVIDER: GSE252267 | GEO | 2024/01/03

REPOSITORIES: GEO

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Single cell RNA sequencing of valvular interstitial cells and adipose derived mesenchymal stem cells

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