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Predisposal of Interferon Regulatory Factor 1 Deficiency to Accumulate DNA Damage and Promote Osteoarthritis Development in Cartilage [Ad_RNA-seq]

ABSTRACT: To investigate the function of IRF1 in chondrocytes, we performed transcriptome analysis in priamry mouse articular chondrocytes. Using adenovirus expressing mouse Irf1 (Ad-Irf1) or expressing eGFP (Ad-eGFP), Irf1 was overexpressed in mouse chondrocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE252509 | GEO | 2024/03/04

REPOSITORIES: GEO

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Predisposal of Interferon Regulatory Factor 1 Deficiency to Accumulate DNA Damage and Promote Osteoarthritis Development in Cartilage [RNA-seq]

Project description:To investigate the function of IRF1 in chondrocytes, we performed transcriptome analysis in priamry mouse articular chondrocytes. Using control and Irf1 siRNA, gene expression profiles were analyzed in depletion of Irf1

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Predisposal of Interferon Regulatory Factor 1 Deficiency to Accumulate DNA Damage and Promote Osteoarthritis Development in Cartilage [ATAC-seq]

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