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Adipose-derived mesenchymal stem cell extracellular vesicles downregulate inflammation in osteoarthritis chondrocytes and cartilage explants

ABSTRACT: Osteoarthritis (OA) is a joint condition associated with articular cartilage loss, low-grade synovitis and alterations in subchondral bone and periarticular tissues. In OA, the interest for mesenchymal stem cell (MSC)-EV therapeutic applications has increased. We have assessed the immunomodulary properties of adipose-derived MSCs (AD-MSCs) microvesicles (MV) and exosomes (EX) in interleukin (IL)-1β stimulated OA chondrocytes and cartilage explants and characterized them by mass spectrometry in order to uncover novel mediators in (AD-MSC)-EV immunomodulation.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): White Adipose Tissue

SUBMITTER: Luz Valero

LAB HEAD: María José Alcaraz

PROVIDER: PXD009077 | Pride | 2022-02-23

REPOSITORIES: pride

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			Action	DRS
	MT_160225_ex32.wiff	Wiff
	MT_160225_ex32.wiff.scan	Wiff
	MT_160225_ex32_MGFPeaklist.mgf	Mgf
	MT_160225_ex32_MGFPeaklist.pride.mgf.gz	Mgf
	MT_160225_exFe3.wiff	Wiff

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