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Next Generation Sequencing Quantitative Analysis of altered expression of genes in BCa cells-induced PDGFRα+ITGA11+ CAFs and other CAFs

ABSTRACT: The cellular diversity of stromal compartment within the tumor microenvironment might change dynamically as tumors evolve that allowing distant dissemination of tumor cells and informing the treatment options. We used single cell RNA sequencing (scRNA-seq) to provide a detailed insight of cellular components feature in bladder cancer and identify that PDGFRα+ITGA11+ CAFs were essential for lymphatic metastasis of bladder cancer. To identify molecular mechanism of PDGFRα+ITGA11+ CAFs formation, next generation sequencing (NSG) was performed to explore the upregulated genes in bladder cancer-induced PDGFRα+ITGA11+ CAFs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE252645 | GEO | 2024/02/16

REPOSITORIES: GEO

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