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Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways

ABSTRACT: Gp130 dependent gene expression was analyzed in a previously established hepatocyte-specific gp130-knockout mouse model. Whole transcriptome analysis for isolated hepatocytes was performed to measure tissue specific responses after proinflammatory stimulus with IL-6 across different time points. We observed differences in the hepatocyte-specific transcriptional gp130 dependent response for genes associated with different aspects of the innate immune system. Our findings suggest a complex network of tightly-linked genes involved in the early activation of different parts of the innate immune response including acute phase proteins, complement and coagulation cascade.

ORGANISM(S): Mus musculus

PROVIDER: GSE25278 | GEO | 2010/11/13

SECONDARY ACCESSION(S): PRJNA134817

REPOSITORIES: GEO

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Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways

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