Transcriptomics

Dataset Information

0

Hippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity


ABSTRACT: MHC class I (MHC-I)-mediated tumor antigen processing and presentation (APP) pathway is essential for recruitment and activation of cytotoxic CD8+ T lymphocytes (CD8+ CTLs). However, this pathway is frequently dysregulated in many cancers, thus leading to a failure of immunotherapy. Here, we reported that activation of the tumoral intrinsic Hippo pathway positively correlated with the expression of MHC-I APP genes and the abundance of CD8+ CTLs in mouse tumors and patients. Blocking the Hippo pathway effector YAP/TEAD potently improved antitumor immunity. Mechanistically, the YAP/TEAD complex cooperated with the NuRD complex to repress the NLRC5 transcription. The upregulation of NLRC5 by YAP/TEAD depletion or pharmacological inhibition increased the expression of MHC-I APP genes and enhanced CD8+ CTLmediated killing of cancer cells. Collectively, our results suggest a novel tumorpromoting function of YAP depending on NLRC5 to impair MHC-I APP pathway and provide a rationale for inhibiting YAP activity in immunotherapy for cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE253053 | GEO | 2024/02/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2008-11-20 | E-GEOD-12498 | biostudies-arrayexpress
2016-02-11 | E-GEOD-73396 | biostudies-arrayexpress
2015-08-25 | E-GEOD-61852 | biostudies-arrayexpress
2024-07-08 | GSE269899 | GEO
2023-10-04 | GSE222960 | GEO
2023-10-04 | GSE222962 | GEO
2024-06-16 | PXD043500 | Pride
2023-12-31 | GSE235788 | GEO
2024-05-31 | GSE252142 | GEO
2017-06-20 | E-MTAB-5395 | biostudies-arrayexpress