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RNA sequencing of PART1 knockdown by siRNA in ovarian cancer cells

ABSTRACT: The expression of lncRNA PART1 was found to be significantly upregulated in platinum-sensitive patients with ovarian cancer, and this upregulation was positively correlated with a favorable prognosis. Cellular experiments demonstrated that inhibition of PART1 led to cellular senescence and increased resistance to cisplatin and PARP inhibitors. Thus, LncRNA PART1 is a novel target for overcoming resistance to PARP inhibitors in ovarian cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE253450 | GEO | 2024/02/01

REPOSITORIES: GEO

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