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Single-cell 5-hydroxymethyl cytosine dynamics during remote memory formation

ABSTRACT: We introduce the Split-Pool based Epigenetic Decoding (SPEED) method, a combinatorial barcoding strategy enhancing the throughput of single-cell 5-hydroxymethyl cytosine (5hmC) or 5-methylcytosine (5mC) profiling. SPEED enables simultaneous, unbiased examination of 5hmC traits across distinct brain regions, surpassing limitations of individual cell scrutiny. Using SPEED we unveil dynamic 5hmC patterns linked to remote memory formation in the brain.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE254382 | GEO | 2025/01/01

REPOSITORIES: GEO

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Single-cell 5-hydroxymethyl cytosine dynamics during remote memory formation

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